- Talk to Leah in New Tristram.
- Enter the Caverns of Araneae in the Wortham Bluffs north of Wortham.
- Search for the Chamber of Queen Araneae.
- Talk to the woman trapped in the web in the Chamber of Queen Araneae.
- Kill Queen Araneae in the Chamber of Queen Araneae.
- Harvest the Pool of Venom in the Chamber of Queen Araneae.
- Free Karyna with the venom in the Chamber of Queen Araneae.
- Go out into the Highlands Crossing from the Chamber of Queen Araneae with Karyna.
- Talk to Karyna in the Highlands Crossing.
- Find the Khazra Staff on Karyna's Lost Wagon in the Southern Highlands.
- Approach the Khazra Barricade with the Khazra Staff in the northern part of the Southern Highlands.
- Find Leoric's Manor Courtyard past the Northern Highlands and Leoric's Hunting Grounds.
- Enter Leoric's Manor at the peak of the Highlands.
- Explore Leoric's Manor.
- Kill the cultists.
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