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Obsession is the rune word 'ZodIstLemLumIoNef' for staves in Diablo II: Resurrected. Obsession is an endgame runeword for sorceresses. It is inaccessible to all except the very wealthy and very lucky, thanks to the Ist, Lem, and particularly Zod rune required.

This runeword provides massive bonuses to all skills, FCR, FHR, resistances, life and mana, as well as defensive Weaken proc. It is justified by the fact that it can be created in staves only, taking two slots of equipment. The runeword itself does not provide more skill bonus than classic Heart of the Oak (or any unique orb) + Spirit combo, but if made in a staff with right +3 staffmod, it can provide a whopping +7 bonus to the relevant skills. Such staves are very rare, however, since the only ones with 6 sockets are War Staff and its exceptional and elite versions.

Compared to the Heart of the Oak/Spirit combination that has been a sorceress staple since Lord of Destruction, Obsession lags slightly in terms of potential Faster Cast Rate; however, it is more powerful defensively for a couple of reasons. First, it requires much less strength to wield than Spirit (0-34 depending on the base, while Spirit requires a minimum of 156 for a Monarch base), allowing many more stat points to be invested into vitality. Secondly, its unusual chance to proc Weaken greatly reduces the physical damage mobs can deal to the sorceress.

Result:
Indestructible
24% Chance to cast level 10 Weaken when struck
+4 To All Skills
+65% Faster Cast Rate
+60% Faster Hit Recovery
Knockback
+10 To Vitality
+10 To Energy
Increase Maximum Life 15-25% (varies)
Regenerate Mana 15-30% (varies)
All Resistances +60-70 (varies)
75% Extra Gold from Monsters
30% Better Chance of Getting Magic Items