Mephisto's Brain is an item needed in the Pandemonium Event. It is one of the three major keys represented by body parts of the Prime Evils, the other two being Diablo's Horn and Baal's Eye. Putting the Brain along with the Horn and the Eye in the Horadric Cube in Harrogath on Hell difficulty opens a portal leading you to Uber Tristram where the ultimate challenge awaits... This item or equipment article is a stub. You can help the Diablo Wiki to become more awesome by expanding it. Pandemonium Event Locations — Forgotten Sands • Furnace of Pain • Matron's Den • Über Tristram Bosses Keywardens — Countess • Summoner • Nihlathak Sub-bosses — Über Duriel • Über Izual • Lilith Über Tristram bosses — Über Baal • Pandemonium Diablo • Über Mephisto Items Keys — Key of Hate • Key of Terror • Key of Destruction Organs — Mephisto's Brain • Diablo's Horn • Baal's Eye Rewards — Hellfire Torch • Standard of Heroes Diablo II Quest Items Act I — Scroll of Inifuss • Horadric Malus Act II — Horadric Scroll • Book of Skill • Horadric Cube • Staff of Kings • Amulet of the Viper • Horadric Staff Act III — Jade Figurine • Golden Bird • Potion of Life • The Gidbinn • Lam Esen's Tome • Khalim's Eye • Khalim's Brain • Khalim's Heart • Khalim's Flail • Khalim's Will Act IV — Mephisto's Soulstone • Hell Forge Hammer Act V — Malah's Potion • Scroll of Resistance The Secret Cow Level — Wirt's Leg World Event — Stone of Jordan Pandemonium Event — Key of Terror • Key of Hate • Key of Destruction • Mephisto's Brain • Diablo's Horn • Baal's Eye Retrieved from "https://diablo.fandom.com/wiki/Mephisto%27s_Brain?oldid=186142" Categories: Item article stubs Quests Quest Items Add category Cancel Save Community content is available under CC-BY-SA unless otherwise noted.