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Human Cartilage was a Legendary Crafting Material in Diablo III. It requires a Character Level of 1 to use, is account bound, and may be stacked up to 1000 times. It was required for the crafting of the Wall of Man legendary shield. As of patch 2.0.6., it no longer drops, and existing pieces may be sold for 50,000 Gold.

The item only dropped from unique Unburied:

"The unburied's insatiable appetite for human remains makes a perverse sort of sense when one considers that they were created from congealed masses of dead bodies." — Abd al-Hazir

Diablo III Crafting Materials

Regular Salvaged and Dropped Materials