Mephisto casting Hellish Projectile.
Hellish Projectile (also known as Skull Missile) is a lethal Monster Skill and the signature move of Mephisto, the Act Boss of Act III in Diablo II.
Hellish Projectile looks like a white, blazing orb and is fired in a straight line. An 'incoming missile' sound can be heard as well.
Hellish Projectile can be very dangerous as it deals horrible damage, usually killing Hirelings and minions in a single hit. Players can expect to relinquish at least a third of their health. Mephisto only uses Skull Missile when at range, so closing in on him should remove the danger.
Damaging Skills
Fire — Apocalypse • Eruption • Fire Arrow • Fireball • Fire Bolt • Fire Hit • Firestorm • Fire Wall • Flame Circle • Grenade • Hydra • Incinerate • Incineration Nova • Inferno • Meteor • Minefield
Ice — Arctic Blast • Blizzard • Cold Touch • Fire Hit (Cold) • Freezing Charge • Frost Bolt • Glacial Spike • Hoarfrost • Ice Shards
Poison — Poison Bolt • Poison Breath • Poison Cloud • Poison Spit • Poison Spray • Poison Sting • Poison Strike
Lightning — Lightning • Lightning Arrow • Lightning Globe • Lightning Storm • Red Lightning Hose • Shocking Hit • Spark Defense • Thunderbolt
Physical — Bite • Blast Wave • Blow Dart • Charge (Berserk Charge) • Cleave • Corpse Cannon • Destructive Strike • Divebomb • Grab • Ground Spikes • Ground Tentacle • Leap • Javelin • Leech-life Ball • Pummel •Quake • Quill Dart • Slam • Snatch • Spine Dart • Strike • Swipe • Sweep • Whirlwind
Wind — Cyclone • Gust • Tornado
Magic — Beam • Blade Beam • Blast • Bomb • Bone Spirit • Cataclysm • Hellish Projectile • Nova • Slow Time • Tide • Torrent • Unholy Bolt • Volley • Wave
Non-damaging Skills
Indirect Attack — Blood Mana • Curses • Mana Rift • Minion Frenzy • Putrify • Spin Web • Stun • Vortex
Spawning — Bone Prison • Festering Appendages • Lay Egg • Minefield • Mystifying Growth • Revive • Summon Minion • Totem
Self-effect — Bone Armor • Burrow • Effigy • Fly • Frenzy • Heal • Shell • Teleport • Vile Effigy