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For the equippable item, see Hand of the Prophet (Focus).
"I am not from Caldeum. I learned these spells fifteen hundred years ago. My sisters and I pledged our service to a man of great power. We called him The Prophet. He trained us and placed us in a magical slumber to awaken in this era. I am to prevent the Lords of Hell from invading."

- Eirena(src)

The Hand of the Prophet was a sisterhood, of which Eirena is the only living member. Its sisters are generally called Enchantresses.


It was created by the Prophet (an angel in disguise) approximately 1500 years before the End of Days. When Eirena and her sisters killed their Vizjerei masters, the Prophet found them and cured the curse those Mages had bestowed upon the girls with their dying breaths. Foreseeing the dark events of the distant future, the Prophet took the girls with him, forming a sisterhood named Hand of the Prophet. He trained them in magic, augmenting the skills the sisters acquired before. It is not specified how numerous the sisterhood was, but not all of the sisters were actually siblings[1].

As no mortal man (or, in this case, woman) could survive that long, the Prophet placed the sisters in a dreamless slumber (a kind of stasis spell), with the goal of awakening ages afterwards, and aid The Nephalem against the Evils. He chose one of the sisters, the most powerful (i.e. Eirena), asking all others if they are willing to sacrifice their lives for hers. Before he cast the spell of binding, each of them could leave without any thought of shame, yet only Lysa did so.[2]. The sisters apparently went into stasis at various locations.[3]

Shortly before finding The Nephalem, the hideout has been breached. Demons under Lysa's command killed most, if not all, sisters (except Eirena), some in combat and some in their sleep, and dragged their souls to Pandemonium. They could not break the binding spell, however, and were forced to withdraw, leaving Eirena to wake up alone later.[1][4]

When Eirena awoke 1500 years later, she encountered The Nephalem. Her companion(s) accompanied her to to the Lair of the Prophet, where Lysa was waiting for her, using the souls of dead sisters as a bait.

After defeating Lysa, Eirena decided to rebuild the sisterhood, in case Sanctuary ever needs their help again, but instead of sleeping for centuries, they would rather pass knowledge from generation to generation.[4]

Known Members[]

"Tell me about this sisterhood of yours."
"We are the hand of the Prophet. The souls of the virtuous."
"Oh, never mind."
"But I was not finished!"
"Really, it's not going to work."

- Lyndon and Eirena(src)