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Frozen Blood was a Legendary Crafting Material in Diablo III. It requires a Character Level of 1 to use, is account bound, and may be stacked up to 1000 times. It was required for the crafting of the Utar's Roar one-handed axe. As of patch 2.0.6., it no longer drops, and existing vials may be sold for 50,000 Gold.
The item only dropped from Chiltara. Note that she also dropped Urn of Quickening, and still drops Gibbering Gemstone, but was not guaranteed to drop any of the three. Because of her rare spawning in Caverns of Frost Level 2, it could take a lot of runs to obtain this item.
Only the blood of Chiltara runs this cold.